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Thyroid

TSH

TSH is the hormone your pituitary uses to steer your thyroid and the most sensitive screen of your thyroid function.

What is TSH?

TSH is the hormone your pituitary uses to steer your thyroid. It works as a thermostat: when your thyroid hormone drops, the pituitary turns TSH up to push the thyroid harder; when there is enough, TSH falls. So TSH moves in the opposite direction to your thyroid's output — a high TSH points to an underactive thyroid, a low one to an overactive thyroid. Because small changes produce large swings, TSH is the most sensitive first-line screen. When it is abnormal, free T4 is added to clarify what is happening.

Why is TSH relevant?

Your thyroid sets the pace of your whole metabolism. An under- or over-active gland is common, often goes unnoticed, and is very treatable once found. Symptoms like fatigue, weight changes, feeling cold, low mood, hair thinning, or palpitations fit exactly the picture a single TSH can start to explain. The direction tells the story: a high TSH fits an underactive thyroid, a low one an overactive thyroid. A mildly raised TSH often normalises on its own and is usually watched rather than treated straight away. A markedly abnormal value is more clearly significant and should be reviewed with a clinician alongside free T4.

TSH high or low — what it means

A single TSH is a snapshot. It is highest in the morning and falls through the day, so timing matters when comparing results. Biotin supplements (common in hair and nail products) can distort the reading — pause them a few days before testing. A borderline or abnormal value is best repeated a few weeks later rather than acted on from one reading. A high TSH usually points to an underactive thyroid, often from the autoimmune condition Hashimoto's. A low TSH usually points to an overactive thyroid. TSH is not something you adjust with lifestyle the way you might lower LDL or CRP — treatment is medical. Any persistently abnormal value should be worked up with a doctor.

TSH reference ranges

Normal (adults)General reference range; cut-offs differ per lab and life stage.0.4-4.0 mIU/L
Markedly raisedFits an underactive thyroid; review with a clinician alongside free T4.> 10 mIU/L
SuppressedFits an overactive thyroid; review with a clinician alongside free T4.< 0.1 mIU/L

Cut-offs vary between laboratories and methods and shift with age and pregnancy. Always read your value against the range printed on your own result. TSH is also reported as mU/L or µIU/mL (the same unit).

Educational information only — not medical advice. Consult a healthcare professional for clinical decisions.

Read about our scientific approachRead the guide: Hormones

Frequently asked questions

What is a normal TSH level?

A general adult reference range runs roughly 0.4-4.0 mIU/L (the same as mU/L or µIU/mL). The exact cut-offs are lab-dependent and shift with age and pregnancy, so always read your value against the range printed on your own result.

What does a high TSH mean?

TSH moves in the opposite direction to your thyroid: a high TSH means your pituitary is shouting at an underactive thyroid (hypothyroidism). A raised TSH with a still-normal free T4 is called 'subclinical' and is often watched first. The risk of progressing to overt hypothyroidism only becomes meaningful above roughly 10 mIU/L.

What does a low TSH mean?

A low or suppressed TSH points to an overactive thyroid (hyperthyroidism). A TSH below 0.1 mIU/L is clearly suppressed and should be reviewed with a clinician alongside free T4.

When is an abnormal TSH a concern?

A mildly raised TSH often normalises on its own and is usually watched rather than treated straight away. A TSH well above 10 mIU/L, or a suppressed TSH below 0.1 mIU/L, is clearly significant and should be reviewed with a clinician alongside free T4.

What can distort my TSH result?

TSH follows a daily rhythm and is highest in the morning, so the time of your blood draw matters. Biotin supplements (common in hair and nail products) can interfere with the assay and mimic an overactive thyroid — pause them a few days before testing. A borderline or abnormal value is best repeated a few weeks later; after a thyroid-medication dose change, re-test only after 6-8 weeks.

TSH is one of the biomarkers in the Optimize blood test. Book a blood draw at any of 238+ partner labs in the Netherlands, or upload your existing results in the app.

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